2zjz
From Proteopedia
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<StructureSection load='2zjz' size='340' side='right'caption='[[2zjz]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2zjz' size='340' side='right'caption='[[2zjz]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2zjz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2zjz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZJZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | |
| - | <tr id=' | + | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjz OCA], [https://pdbe.org/2zjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjz RCSB], [https://www.ebi.ac.uk/pdbsum/2zjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjz OCA], [https://pdbe.org/2zjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zjz RCSB], [https://www.ebi.ac.uk/pdbsum/2zjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
| - | [[Category: Heterotrimeric G-protein GTPase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Kohno | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Morikawa | + | [[Category: Kohno T]] |
| - | [[Category: Muroya | + | [[Category: Morikawa T]] |
| - | [[Category: Sugio | + | [[Category: Muroya A]] |
| - | [[Category: Wakamatsu | + | [[Category: Sugio S]] |
| - | + | [[Category: Wakamatsu K]] | |
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Revision as of 13:40, 1 November 2023
Structure of the K349P mutant of Gi alpha 1 subunit bound to GDP
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