1nw1

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[[Image:1nw1.jpg|left|200px]]
[[Image:1nw1.jpg|left|200px]]
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{{Structure
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|PDB= 1nw1 |SIZE=350|CAPTION= <scene name='initialview01'>1nw1</scene>, resolution 2.02&Aring;
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The line below this paragraph, containing "STRUCTURE_1nw1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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{{STRUCTURE_1nw1| PDB=1nw1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw1 OCA], [http://www.ebi.ac.uk/pdbsum/1nw1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nw1 RCSB]</span>
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'''Crystal Structure of Choline Kinase'''
'''Crystal Structure of Choline Kinase'''
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[[Category: Peisach, D.]]
[[Category: Peisach, D.]]
[[Category: Xu, Z.]]
[[Category: Xu, Z.]]
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[[Category: choline kinase]]
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[[Category: Choline kinase]]
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[[Category: phospholipid synthesis]]
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[[Category: Phospholipid synthesis]]
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[[Category: protein kinase fold]]
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[[Category: Protein kinase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:02:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:36:23 2008''
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Revision as of 00:02, 3 May 2008

Image:1nw1.jpg

Template:STRUCTURE 1nw1

Crystal Structure of Choline Kinase


Overview

Choline kinase catalyzes the ATP-dependent phosphorylation of choline, the first committed step in the CDP-choline pathway for the biosynthesis of phosphatidylcholine. The 2.0 A crystal structure of a choline kinase from C. elegans (CKA-2) reveals that the enzyme is a homodimeric protein with each monomer organized into a two-domain fold. The structure is remarkably similar to those of protein kinases and aminoglycoside phosphotransferases, despite no significant similarity in amino acid sequence. Comparisons to the structures of other kinases suggest that ATP binds to CKA-2 in a pocket formed by highly conserved and catalytically important residues. In addition, a choline binding site is proposed to be near the ATP binding pocket and formed by several structurally flexible loops.

About this Structure

1NW1 is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The crystal structure of choline kinase reveals a eukaryotic protein kinase fold., Peisach D, Gee P, Kent C, Xu Z, Structure. 2003 Jun;11(6):703-13. PMID:12791258 Page seeded by OCA on Sat May 3 03:02:45 2008

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