2zvy

From Proteopedia

(Difference between revisions)

Current revision

Structure of the periplasmic domain of MotB from Salmonella (crystal form II)

Structural highlights

2zvy is a 2 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.75Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MOTB_SALTY MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Torque generation in the Salmonella flagellar motor is coupled to translocation of H(+) ions through the proton-conducting channel of the Mot protein stator complex. The Mot complex is believed to be anchored to the peptidoglycan (PG) layer by the putative peptidoglycan-binding (PGB) domain of MotB. Proton translocation is activated only when the stator is installed into the motor. We report the crystal structure of a C-terminal periplasmic fragment of MotB (MotB(C)) that contains the PGB domain and includes the entire periplasmic region essential for motility. Structural and functional analyses indicate that the PGB domains must dimerize in order to form the proton-conducting channel. Drastic conformational changes in the N-terminal portion of MotB(C) are required both for PG binding and the proton channel activation.

Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB.,Kojima S, Imada K, Sakuma M, Sudo Y, Kojima C, Minamino T, Homma M, Namba K Mol Microbiol. 2009 Aug;73(4):710-8. Epub 2009 Jul 21. PMID:19627504^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kojima S, Imada K, Sakuma M, Sudo Y, Kojima C, Minamino T, Homma M, Namba K. Stator assembly and activation mechanism of the flagellar motor by the periplasmic region of MotB. Mol Microbiol. 2009 Aug;73(4):710-8. Epub 2009 Jul 21. PMID:19627504 doi:10.1111/j.1365-2958.2009.06802.x

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zvy"

@@ Line 3: / Line 3: @@
 <StructureSection load='2zvy' size='340' side='right'caption='[[2zvy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2zvy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZVY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2zvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVY FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zov|2zov]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvy OCA], [http://pdbe.org/2zvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zvy RCSB], [http://www.ebi.ac.uk/pdbsum/2zvy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvy ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvy OCA], [https://pdbe.org/2zvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvy RCSB], [https://www.ebi.ac.uk/pdbsum/2zvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvy ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/MOTB_SALTY MOTB_SALTY]] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
+[https://www.uniprot.org/uniprot/MOTB_SALTY MOTB_SALTY] MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Homma, M]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-[[Category: Imada, K]]
+[[Category: Homma M]]
-[[Category: Kojima, S]]
+[[Category: Imada K]]
-[[Category: Namba, K]]
+[[Category: Kojima S]]
-[[Category: 2-layer sandwich]]
+[[Category: Namba K]]
-[[Category: Bacterial flagellum]]
-[[Category: Cell inner membrane]]
-[[Category: Cell membrane]]
-[[Category: Chemotaxis]]
-[[Category: Flagellar rotation]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Transmembrane]]

2zvy

From Proteopedia

Current revision

Structure of the periplasmic domain of MotB from Salmonella (crystal form II)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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