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2zzx

From Proteopedia

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Current revision (14:04, 1 November 2023) (edit) (undo)
 
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<StructureSection load='2zzx' size='340' side='right'caption='[[2zzx]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='2zzx' size='340' side='right'caption='[[2zzx]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zzx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zzx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZZX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0766 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zzx OCA], [https://pdbe.org/2zzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zzx RCSB], [https://www.ebi.ac.uk/pdbsum/2zzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zzx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zzx OCA], [https://pdbe.org/2zzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zzx RCSB], [https://www.ebi.ac.uk/pdbsum/2zzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zzx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLBP_THET8 TLBP_THET8] Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of lactate. This protein specifically binds L-lactate.[UniProtKB:P37676]<ref>PMID:19631222</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thet8]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Akiyama, N]]
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[[Category: Akiyama N]]
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[[Category: Miki, K]]
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[[Category: Miki K]]
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[[Category: Takeda, K]]
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[[Category: Takeda K]]
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[[Category: Lactate]]
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[[Category: Periplasmic substrate binding protein]]
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[[Category: Transport protein]]
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[[Category: Trap transporter]]
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Current revision

Crystal Structure of a Periplasmic Substrate Binding Protein in Complex with Lactate

PDB ID 2zzx

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