3a7n

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Current revision (14:14, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3a7n' size='340' side='right'caption='[[3a7n]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3a7n' size='340' side='right'caption='[[3a7n]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A7N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zhx|2zhx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ung, Rv2976c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a7n OCA], [https://pdbe.org/3a7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a7n RCSB], [https://www.ebi.ac.uk/pdbsum/3a7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a7n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a7n OCA], [https://pdbe.org/3a7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a7n RCSB], [https://www.ebi.ac.uk/pdbsum/3a7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a7n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU]] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
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[https://www.uniprot.org/uniprot/UNG_MYCTU UNG_MYCTU] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Uridine nucleosidase]]
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[[Category: Kaushal PS]]
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[[Category: Kaushal, P S]]
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[[Category: Talawar RK]]
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[[Category: Talawar, R K]]
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[[Category: Varshney U]]
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[[Category: Varshney, U]]
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[[Category: Vijayan M]]
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[[Category: Vijayan, M]]
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[[Category: Citrate as protein ligand]]
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[[Category: Dna damage]]
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[[Category: Dna repair]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor design]]
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[[Category: Ligand binding]]
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[[Category: Ung-dna complex]]
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[[Category: Ung-ugi interaction]]
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Current revision

Crystal structure of uracil-DNA glycosylase from Mycobacterium tuberculosis

PDB ID 3a7n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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