1os2

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(New page: 200px<br /> <applet load="1os2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1os2, resolution 2.15&Aring;" /> '''Ternary enzyme-prod...)
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Revision as of 16:29, 12 November 2007

Image:1os2.gif

1os2, resolution 2.15Å

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Ternary enzyme-product-inhibitor complexes of human MMP12

Disease

Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

1OS2 is a Single protein structure of sequence from Homo sapiens with ZN, CA, ACT, AZI and HAE as ligands. Active as Macrophage elastase, with EC number 3.4.24.65 Full crystallographic information is available from OCA.

Reference

X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751

Page seeded by OCA on Mon Nov 12 18:35:57 2007

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