1nwy

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[[Image:1nwy.gif|left|200px]]
[[Image:1nwy.gif|left|200px]]
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{{Structure
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|PDB= 1nwy |SIZE=350|CAPTION= <scene name='initialview01'>1nwy</scene>, resolution 3.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1nwy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZIT:AZITHROMYCIN'>ZIT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1nwy| PDB=1nwy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nwy OCA], [http://www.ebi.ac.uk/pdbsum/1nwy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nwy RCSB]</span>
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}}
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'''COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN'''
'''COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN'''
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[[Category: Zarivach, R.]]
[[Category: Zarivach, R.]]
[[Category: 50]]
[[Category: 50]]
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[[Category: azithromycin]]
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[[Category: Azithromycin]]
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[[Category: ketolide]]
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[[Category: Ketolide]]
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[[Category: macrolide]]
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[[Category: Macrolide]]
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[[Category: ribosomal]]
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[[Category: Ribosomal]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:04:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:36:41 2008''
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Revision as of 00:04, 3 May 2008

Image:1nwy.gif

Template:STRUCTURE 1nwy

COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN


Overview

The azalide azithromycin and the ketolide ABT-773, which were derived by chemical modifications of erythromycin, exhibit elevated activity against a number of penicillin- and macrolide-resistant pathogenic bacteria. Analysis of the crystal structures of the large ribosomal subunit from Deinococcus radiodurans complexed with azithromycin or ABT-773 indicates that, despite differences in the number and nature of their contacts with the ribosome, both compounds exert their antimicrobial activity by blocking the protein exit tunnel. In contrast to all macrolides studied so far, two molecules of azithromycin bind simultaneously to the tunnel. The additional molecule also interacts with two proteins, L4 and L22, implicated in macrolide resistance. These studies illuminated and rationalized the enhanced activity of the drugs against specific macrolide-resistant bacteria.

About this Structure

1NWY is a Protein complex structure of sequences from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Structural basis for the antibiotic activity of ketolides and azalides., Schlunzen F, Harms JM, Franceschi F, Hansen HA, Bartels H, Zarivach R, Yonath A, Structure. 2003 Mar;11(3):329-38. PMID:12623020 Page seeded by OCA on Sat May 3 03:04:41 2008

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