1os9

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(New page: 200px<br /> <applet load="1os9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1os9, resolution 1.85&Aring;" /> '''Binary enzyme-produ...)
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Revision as of 16:29, 12 November 2007

Image:1os9.gif

1os9, resolution 1.85Å

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Binary enzyme-product complexes of human MMP12

Disease

Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

1OS9 is a Single protein structure of sequence from Homo sapiens with ZN and CA as ligands. Active as Macrophage elastase, with EC number 3.4.24.65 Full crystallographic information is available from OCA.

Reference

X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751

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