This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3du7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:14, 1 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3du7' size='340' side='right'caption='[[3du7]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
<StructureSection load='3du7' size='340' side='right'caption='[[3du7]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3du7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DU7 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3du7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DU7 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN2:2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE'>CN2</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=HOS:PHOMOPSIN+A'>HOS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sa0|1sa0]], [[1z2b|1z2b]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN2:2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE'>CN2</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=HOS:PHOMOPSIN+A'>HOS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Stmn4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3du7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3du7 OCA], [https://pdbe.org/3du7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3du7 RCSB], [https://www.ebi.ac.uk/pdbsum/3du7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3du7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3du7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3du7 OCA], [https://pdbe.org/3du7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3du7 RCSB], [https://www.ebi.ac.uk/pdbsum/3du7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3du7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/TBA1C_BOVIN TBA1C_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[https://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[https://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
+
[https://www.uniprot.org/uniprot/TBA1C_BOVIN TBA1C_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 39: Line 38:
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Cormier, A]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Gigant, B]]
+
[[Category: Cormier A]]
-
[[Category: Knossow, M]]
+
[[Category: Gigant B]]
-
[[Category: Marchand, M]]
+
[[Category: Knossow M]]
-
[[Category: Ravelli, R B]]
+
[[Category: Marchand M]]
-
[[Category: Alpha-tubulin]]
+
[[Category: Ravelli RB]]
-
[[Category: Beta-tubulin]]
+
-
[[Category: Cell cycle]]
+
-
[[Category: Colchicine]]
+
-
[[Category: Gtp-binding]]
+
-
[[Category: Gtpase]]
+
-
[[Category: Microtubule]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phomopsin some]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Stathmin]]
+
-
[[Category: Tubulin]]
+

Current revision

Tubulin-colchicine-phomopsin A: Stathmin-like domain complex

PDB ID 3du7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3du7"
Personal tools