3fog

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Current revision (15:30, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3fog' size='340' side='right'caption='[[3fog]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3fog' size='340' side='right'caption='[[3fog]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fog]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FOG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNX17, KIAA0064 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fog OCA], [https://pdbe.org/3fog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fog RCSB], [https://www.ebi.ac.uk/pdbsum/3fog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fog ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fog OCA], [https://pdbe.org/3fog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fog RCSB], [https://www.ebi.ac.uk/pdbsum/3fog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fog ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN]] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>
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[https://www.uniprot.org/uniprot/SNX17_HUMAN SNX17_HUMAN] Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).<ref>PMID:15121882</ref> <ref>PMID:15769472</ref> <ref>PMID:16712798</ref> <ref>PMID:19005208</ref> <ref>PMID:22492727</ref> <ref>PMID:21512128</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berg, S Van Den]]
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[[Category: Berglund H]]
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[[Category: Berglund, H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Collins R]]
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[[Category: Collins, R]]
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[[Category: Dahlgren LG]]
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[[Category: Dahlgren, L G]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Flodin S]]
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[[Category: Flodin, S]]
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[[Category: Flores A]]
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[[Category: Flores, A]]
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[[Category: Graslund S]]
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[[Category: Graslund, S]]
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[[Category: Hammarstrom M]]
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[[Category: Hammarstrom, M]]
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[[Category: Johansson A]]
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[[Category: Johansson, A]]
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[[Category: Johansson I]]
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[[Category: Johansson, I]]
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[[Category: Karlberg T]]
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[[Category: Karlberg, T]]
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[[Category: Kotenyova T]]
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[[Category: Kotenyova, T]]
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[[Category: Lehtio L]]
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[[Category: Lehtio, L]]
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[[Category: Moche M]]
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[[Category: Moche, M]]
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[[Category: Nilsson ME]]
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[[Category: Nilsson, M E]]
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[[Category: Nordlund P]]
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[[Category: Nordlund, P]]
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[[Category: Nyman T]]
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[[Category: Nyman, T]]
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[[Category: Persson C]]
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[[Category: Persson, C]]
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[[Category: Sagemark J]]
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[[Category: Structural genomic]]
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[[Category: Schueler H]]
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[[Category: Sagemark, J]]
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[[Category: Siponen MI]]
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[[Category: Schueler, H]]
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[[Category: Thorsell AG]]
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[[Category: Siponen, M I]]
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[[Category: Tresaugues L]]
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[[Category: Thorsell, A G]]
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[[Category: Van Den Berg S]]
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[[Category: Tresaugues, L]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Welin M]]
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[[Category: Welin, M]]
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[[Category: Wikstrom M]]
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[[Category: Wikstrom, M]]
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[[Category: Wisniewska M]]
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[[Category: Wisniewska, M]]
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[[Category: Cytoplasm]]
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[[Category: Endosome]]
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[[Category: Helix]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Sgc]]
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[[Category: Transport]]
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Current revision

Crystal structure of the PX domain of sorting nexin-17 (SNX17)

PDB ID 3fog

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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