1ny7
From Proteopedia
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'''COWPEA MOSAIC VIRUS (CPMV)''' | '''COWPEA MOSAIC VIRUS (CPMV)''' | ||
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[[Category: Stauffacher, C V.]] | [[Category: Stauffacher, C V.]] | ||
[[Category: Usha, R.]] | [[Category: Usha, R.]] | ||
| - | [[Category: | + | [[Category: Comovirus]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | [[Category: | + | [[Category: Virus]] |
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Revision as of 00:07, 3 May 2008
COWPEA MOSAIC VIRUS (CPMV)
Overview
Comoviruses are a group of plant viruses in the picornavirus superfamily. The type member of comoviruses, cowpea mosaic virus (CPMV), was crystallized in the cubic space group I23, a = 317 A and the hexagonal space group P6(1)22, a = 451 A, c = 1038 A. Structures of three closely similar nucleoprotein particles were determined in the cubic form. The roughly 300-A capsid was similar to the picornavirus capsid displaying a pseudo T = 3 (P = 3) surface lattice. The three beta-sandwich domains adopt two orientations, one with the long axis radial and the other two with the long axes tangential in reference to the capsid sphere. T = 3 viruses display one or the other of these two orientations. The CPMV capsid was permeable to cesium ions, leading to a disturbance of the beta-annulus inside a channel-like structure, suggesting an ion channel. The hexagonal crystal form diffracted X rays to 3 A resolution, despite the large unit cell. The large ( approximately 200 A) solvent channels in the lattice allow exchange of CPMV cognate Fab fragments. As an initial step in the structure determination of the CPMV/Fab complex, the P6(1)22 crystal structure was solved by molecular replacement with the CPMV model determined in the cubic cell.
About this Structure
1NY7 is a Protein complex structure of sequences from Cowpea mosaic virus. Full crystallographic information is available from OCA.
Reference
The refined crystal structure of cowpea mosaic virus at 2.8 A resolution., Lin T, Chen Z, Usha R, Stauffacher CV, Dai JB, Schmidt T, Johnson JE, Virology. 1999 Dec 5;265(1):20-34. PMID:10603314 Page seeded by OCA on Sat May 3 03:07:31 2008
