3kee

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Current revision (16:11, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3kee' size='340' side='right'caption='[[3kee]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3kee' size='340' side='right'caption='[[3kee]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kee]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kee]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30B:(2R,3AR,10Z,11AS,12AR,14AR)-N-(CYCLOPROPYLSULFONYL)-2-({7-METHOXY-8-METHYL-2-[4-(1-METHYLETHYL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)-5-METHYL-4,14-DIOXO-2,3,3A,4,5,6,7,8,9,11A,12,13,14,14A-TETRADECAHYDROCYCLOPENTA[C]CYCLOPROPA[G][1,6]DIAZACYCLOTETRADECINE-12A(1H)-CARBOXAMIDE'>30B</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kf2|3kf2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30B:(2R,3AR,10Z,11AS,12AR,14AR)-N-(CYCLOPROPYLSULFONYL)-2-({7-METHOXY-8-METHYL-2-[4-(1-METHYLETHYL)-1,3-THIAZOL-2-YL]QUINOLIN-4-YL}OXY)-5-METHYL-4,14-DIOXO-2,3,3A,4,5,6,7,8,9,11A,12,13,14,14A-TETRADECAHYDROCYCLOPENTA[C]CYCLOPROPA[G][1,6]DIAZACYCLOTETRADECINE-12A(1H)-CARBOXAMIDE'>30B</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hepacivirin Hepacivirin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.98 3.4.21.98] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kee OCA], [https://pdbe.org/3kee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kee RCSB], [https://www.ebi.ac.uk/pdbsum/3kee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kee ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kee OCA], [https://pdbe.org/3kee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kee RCSB], [https://www.ebi.ac.uk/pdbsum/3kee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kee ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P90191_9HEPC P90191_9HEPC]
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepacivirin]]
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[[Category: Hepacivirus C]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cummings, M D]]
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[[Category: Cummings MD]]
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[[Category: Lindberg, J D]]
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[[Category: Lindberg JD]]
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[[Category: Nystrom, S]]
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[[Category: Nystrom S]]
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[[Category: Hcv]]
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[[Category: Hydrolase]]
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[[Category: Macrocycle]]
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[[Category: Noncovalent]]
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[[Category: Ns3]]
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[[Category: Ns4a]]
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[[Category: Tmc435]]
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Current revision

HCV NS3/NS4A complexed with Non-covalent macrocyclic compound TMC435

PDB ID 3kee

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