3ko1

From Proteopedia

(Difference between revisions)

Current revision

Cystal structure of thermosome from Acidianus tengchongensis strain S5

Structural highlights

3ko1 is a 9 chain structure with sequence from Acidianus tengchongensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.7Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q877H2_9CREN

Publication Abstract from PubMed

Thermosomes are group II chaperonins responsible for protein refolding in an ATP-dependent manner. Little is known regarding the conformational changes of thermosomes during their functional cycle due to a lack of high-resolution structure in the open state. Here, we report the first complete crystal structure of thermosome (rATcpnbeta) in the open state from Acidianus tengchongensis. There is a approximately 30 degrees rotation of the apical and lid domains compared with the previous closed structure. Besides, the structure reveals a conspicuous hydrophobic patch in the lid domain, and residues locating in this patch are conserved across species. Both the closed and open forms of rATcpnbeta were also reconstructed by electron microscopy (EM). Structural fitting revealed the detailed conformational change from the open to the closed state. Structural comparison as well as protease K digestion indicated only ATP binding without hydrolysis does not induce chamber closure of thermosome.

Crystal structure of group II chaperonin in the open state.,Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F Structure. 2010 Oct 13;18(10):1270-9. PMID:20947016^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Huo Y, Hu Z, Zhang K, Wang L, Zhai Y, Zhou Q, Lander G, Zhu J, He Y, Pang X, Xu W, Bartlam M, Dong Z, Sun F. Crystal structure of group II chaperonin in the open state. Structure. 2010 Oct 13;18(10):1270-9. PMID:20947016 doi:10.1016/j.str.2010.07.009

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ko1"

@@ Line 3: / Line 3: @@
 <StructureSection load='3ko1' size='340' side='right'caption='[[3ko1]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ko1]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/"acidianus_tengchongenses"_he_et_al._2001 "acidianus tengchongenses" he et al. 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KO1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ko1]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_tengchongensis Acidianus tengchongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KO1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ko1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ko1 OCA], [https://pdbe.org/3ko1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ko1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ko1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ko1 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q877H2_9CREN Q877H2_9CREN]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Acidianus tengchongenses he et al. 2001]]
+[[Category: Acidianus tengchongensis]]
 [[Category: Large Structures]]
-[[Category: Dong, Z]]
+[[Category: Dong Z]]
-[[Category: He, Y]]
+[[Category: He Y]]
-[[Category: Hu, Z]]
+[[Category: Hu Z]]
-[[Category: Huo, Y]]
+[[Category: Huo Y]]
-[[Category: Lander, G]]
+[[Category: Lander G]]
-[[Category: Sun, F]]
+[[Category: Sun F]]
-[[Category: Wang, L]]
+[[Category: Wang L]]
-[[Category: Xu, W]]
+[[Category: Xu W]]
-[[Category: Zhai, Y]]
+[[Category: Zhai Y]]
-[[Category: Zhang, K]]
+[[Category: Zhang K]]
-[[Category: Zhou, Q]]
+[[Category: Zhou Q]]
-[[Category: Zhu, J]]
+[[Category: Zhu J]]
-[[Category: 9-fold symmetry]]
-[[Category: Atp hydrolase]]
-[[Category: Chaperone]]
-[[Category: Double ring]]
-[[Category: Nucleotide-binding]]

3ko1

From Proteopedia

Current revision

Cystal structure of thermosome from Acidianus tengchongensis strain S5

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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