3l21
From Proteopedia
(Difference between revisions)
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<StructureSection load='3l21' size='340' side='right'caption='[[3l21]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3l21' size='340' side='right'caption='[[3l21]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3l21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3l21]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L21 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand= | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KPI:(2S)-2-AMINO-6-[(1-HYDROXY-1-OXO-PROPAN-2-YLIDENE)AMINO]HEXANOIC+ACID'>KPI</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l21 OCA], [https://pdbe.org/3l21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l21 RCSB], [https://www.ebi.ac.uk/pdbsum/3l21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l21 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l21 OCA], [https://pdbe.org/3l21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l21 RCSB], [https://www.ebi.ac.uk/pdbsum/3l21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l21 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DAPA_MYCTU DAPA_MYCTU] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) (Probable).<ref>PMID:18062777</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: 4-hydroxy-tetrahydrodipicolinate synthase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Devenish, S R]] | ||
| - | [[Category: Evans, G L]] | ||
| - | [[Category: Gerrard, J A]] | ||
| - | [[Category: Jamerson, G B]] | ||
| - | [[Category: Schuldt, L]] | ||
| - | [[Category: Weiss, M S]] | ||
| - | [[Category: Amino-acid biosynthesis]] | ||
| - | [[Category: Dapa]] | ||
| - | [[Category: Dhdp]] | ||
| - | [[Category: Diaminopimelate biosynthesis]] | ||
| - | [[Category: Dihydrodipicolinate synthase]] | ||
| - | [[Category: Dimer]] | ||
| - | [[Category: Lyase]] | ||
| - | [[Category: Lysine biosynthesis]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Devenish SR]] |
| - | [[Category: | + | [[Category: Evans GL]] |
| - | [[Category: | + | [[Category: Gerrard JA]] |
| + | [[Category: Jamerson GB]] | ||
| + | [[Category: Schuldt L]] | ||
| + | [[Category: Weiss MS]] | ||
Current revision
The crystal structure of a dimeric mutant of dihydrodipicolinate synthase (DAPA, RV2753C) from Mycobacterium Tuberculosis - DHDPS-A204R
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