3l30

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Current revision (16:19, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3l30' size='340' side='right'caption='[[3l30]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3l30' size='340' side='right'caption='[[3l30]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3l30]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L30 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3L30 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3l30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L30 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBW:4,14-DIHYDRO-8H-[1,3]DIOXOLO[4,5-G]ISOQUINO[3,2-A]ISOQUINOLINE-9,10-DIOL'>DBW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p2p|4p2p]], [[2qvd|2qvd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DBW:4,14-DIHYDRO-8H-[1,3]DIOXOLO[4,5-G]ISOQUINO[3,2-A]ISOQUINOLINE-9,10-DIOL'>DBW</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l30 OCA], [https://pdbe.org/3l30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l30 RCSB], [https://www.ebi.ac.uk/pdbsum/3l30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l30 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3l30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l30 OCA], [http://pdbe.org/3l30 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l30 RCSB], [http://www.ebi.ac.uk/pdbsum/3l30 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l30 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA21B_PIG PA21B_PIG] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Abhilash, J]]
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[[Category: Abhilash J]]
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[[Category: Haridas, M]]
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[[Category: Haridas M]]
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[[Category: Naveen, C]]
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[[Category: Naveen C]]
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[[Category: Ponnuraj, K]]
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[[Category: Ponnuraj K]]
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[[Category: Pradeep, M]]
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[[Category: Pradeep M]]
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[[Category: Prasanth, G K]]
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[[Category: Prasanth GK]]
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[[Category: Sadasivan, C]]
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[[Category: Sadasivan C]]
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[[Category: Dihydroxyberberine]]
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[[Category: Disulfide bond]]
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[[Category: Hydrolase]]
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[[Category: Lipid degradation]]
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[[Category: Lipoprotein]]
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[[Category: Metal-binding]]
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[[Category: Palmitate]]
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[[Category: Phospholipase a2]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: Secreted]]
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Current revision

Crystal structure of porcine pancreatic phospholipase A2 complexed with dihydroxyberberine

PDB ID 3l30

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