1nyl

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[[Image:1nyl.jpg|left|200px]]
[[Image:1nyl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nyl |SIZE=350|CAPTION= <scene name='initialview01'>1nyl</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1nyl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= glnS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_1nyl| PDB=1nyl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyl OCA], [http://www.ebi.ac.uk/pdbsum/1nyl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nyl RCSB]</span>
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}}
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'''Unliganded glutaminyl-tRNA synthetase'''
'''Unliganded glutaminyl-tRNA synthetase'''
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[[Category: Perona, J P.]]
[[Category: Perona, J P.]]
[[Category: Sherlin, L D.]]
[[Category: Sherlin, L D.]]
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[[Category: ligase]]
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[[Category: Ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:08:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:20 2008''
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Revision as of 00:08, 3 May 2008

Image:1nyl.jpg

Template:STRUCTURE 1nyl

Unliganded glutaminyl-tRNA synthetase


Overview

The crystal structure of ligand-free E. coli glutaminyl-tRNA synthetase (GlnRS) at 2.4 A resolution shows that substrate binding is essential to construction of a catalytically proficient active site. tRNA binding generates structural changes throughout the enzyme, repositioning key active site peptides that bind glutamine and ATP. The structure gives insight into longstanding questions regarding the tRNA dependence of glutaminyl adenylate formation, the coupling of amino acid and tRNA selectivities, and the roles of specific pathways for transmission of tRNA binding signals to the active site. Comparative analysis of the unliganded and tRNA-bound structures shows, in detail, how flexibility is built into the enzyme architecture and suggests that the induced-fit transitions are a key underlying determinant of both amino acid and tRNA specificity.

About this Structure

1NYL is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

tRNA-dependent active site assembly in a class I aminoacyl-tRNA synthetase., Sherlin LD, Perona JJ, Structure. 2003 May;11(5):591-603. PMID:12737824 Page seeded by OCA on Sat May 3 03:08:37 2008

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OCA

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