3mhw
From Proteopedia
(Difference between revisions)
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<StructureSection load='3mhw' size='340' side='right'caption='[[3mhw]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='3mhw' size='340' side='right'caption='[[3mhw]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3mhw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3mhw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MHW FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABV:1,3-BENZOTHIAZOL-2-AMINE'>ABV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id=' | + | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhw OCA], [https://pdbe.org/3mhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mhw RCSB], [https://www.ebi.ac.uk/pdbsum/3mhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhw OCA], [https://pdbe.org/3mhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mhw RCSB], [https://www.ebi.ac.uk/pdbsum/3mhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref> | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Chen L-Q]] | |
| - | [[Category: Chen | + | [[Category: Huang M-D]] |
| - | [[Category: Huang | + | [[Category: Jiang L-G]] |
| - | [[Category: Jiang | + | [[Category: Yuan C]] |
| - | [[Category: Yuan | + | |
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Revision as of 16:34, 1 November 2023
The complex crystal Structure of Urokianse and 2-Aminobenzothiazole
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