3p4n

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Current revision (17:02, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3p4n' size='340' side='right'caption='[[3p4n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3p4n' size='340' side='right'caption='[[3p4n]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p4n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p4n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Cali_mammarenavirus Cali mammarenavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zsv|2zsv]], [[2zsw|2zsw]], [[3p4m|3p4m]], [[3p4o|3p4o]], [[3p9l|3p9l]], [[3p9m|3p9m]], [[3pab|3pab]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-K1, H2-K ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4n OCA], [https://pdbe.org/3p4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4n RCSB], [https://www.ebi.ac.uk/pdbsum/3p4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4n OCA], [https://pdbe.org/3p4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4n RCSB], [https://www.ebi.ac.uk/pdbsum/3p4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/NCAP_PIARV NCAP_PIARV]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). [[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cali mammarenavirus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Gras, S]]
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[[Category: Gras S]]
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[[Category: Guillonneau, C]]
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[[Category: Guillonneau C]]
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[[Category: Rossjohn, J]]
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[[Category: Rossjohn J]]
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[[Category: H2-kb]]
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[[Category: Immune system]]
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[[Category: Lcmv]]
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[[Category: Mhc]]
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[[Category: Pv]]
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[[Category: T cell]]
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[[Category: Tcr]]
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[[Category: Viral escape]]
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Current revision

Crystal Structure of H2-Kb in complex with the NP205-PV epitope YTVKFPNM, an 8-mer peptide from PV

PDB ID 3p4n

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