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3pla

From Proteopedia

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Current revision (17:06, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3pla' size='340' side='right'caption='[[3pla]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
<StructureSection load='3pla' size='340' side='right'caption='[[3pla]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pla]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus'] and [https://en.wikipedia.org/wiki/Suls9 Suls9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pla]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus], [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_98/2 Saccharolobus solfataricus 98/2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SSO0939 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus']), rpl7ae, Ssol_1068 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=555311 SULS9]), flpA, SSO0940, C33_014 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 'Saccharolobus solfataricus'])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pla OCA], [https://pdbe.org/3pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pla RCSB], [https://www.ebi.ac.uk/pdbsum/3pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pla ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pla OCA], [https://pdbe.org/3pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pla RCSB], [https://www.ebi.ac.uk/pdbsum/3pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pla ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FLPA_SULSO FLPA_SULSO]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.<ref>PMID:11959980</ref> <ref>PMID:15522081</ref> [[https://www.uniprot.org/uniprot/D0KRE2_SULS9 D0KRE2_SULS9]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326]
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[https://www.uniprot.org/uniprot/D0KRE2_SACS9 D0KRE2_SACS9] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Saccharolobus solfataricus]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Suls9]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Jia, R]]
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[[Category: Saccharolobus solfataricus 98/2]]
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[[Category: Lai, S]]
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[[Category: Synthetic construct]]
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[[Category: Lin, J]]
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[[Category: Jia R]]
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[[Category: Lu, J]]
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[[Category: Lai S]]
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[[Category: Xu, A]]
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[[Category: Lin J]]
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[[Category: Ye, K]]
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[[Category: Lu J]]
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[[Category: Zhang, L]]
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[[Category: Xu A]]
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[[Category: Box c/d rna]]
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[[Category: Ye K]]
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[[Category: Guide rna]]
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[[Category: Zhang L]]
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[[Category: Methyltransferase]]
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[[Category: Rna-binding]]
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[[Category: Rna-protein complex]]
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[[Category: Sam]]
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[[Category: Transferase-rna complex]]
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Current revision

Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus

PDB ID 3pla

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