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1nzg
From Proteopedia
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[[Image:1nzg.gif|left|200px]] | [[Image:1nzg.gif|left|200px]] | ||
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'''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine''' | '''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. | |
==Reference== | ==Reference== | ||
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12790517 12790517] | 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12790517 12790517] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Egli, M.]] | [[Category: Egli, M.]] | ||
[[Category: Manoharan, M.]] | [[Category: Manoharan, M.]] | ||
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[[Category: Prhavc, M.]] | [[Category: Prhavc, M.]] | ||
[[Category: 2'-modified oligonucleotide]] | [[Category: 2'-modified oligonucleotide]] | ||
| - | [[Category: | + | [[Category: A-dna]] |
| - | [[Category: | + | [[Category: Crystal structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:10:34 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:10, 3 May 2008
Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine
Overview
[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification have been synthesized. This modification, a cationic analogue of the 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding affinity to target RNA (but not to DNA) and exceptional resistance to nuclease degradation. Analysis of the crystal structure of a self-complementary oligonucleotide containing a single 2'-O-DMAEOE modification explains the importance of charge factors and gauche effects on the observed antisense properties. 2'-O-DMAEOE modified oligonucleotides are ideal candidates for antisense drugs.
About this Structure
Full crystallographic information is available from OCA.
Reference
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:12790517 Page seeded by OCA on Sat May 3 03:10:34 2008
