3q2h

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Current revision (17:09, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3q2h' size='340' side='right'caption='[[3q2h]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='3q2h' size='340' side='right'caption='[[3q2h]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3q2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3q2h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=QHF:N-[(2S,4S)-1-({4-[2-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)ETHYL]PIPERIDIN-1-YL}SULFONYL)-4-(5-FLUOROPYRIMIDIN-2-YL)-2-METHYLPENTAN-2-YL]-N-HYDROXYFORMAMIDE'>QHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q2g|3q2g]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=QHF:N-[(2S,4S)-1-({4-[2-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)ETHYL]PIPERIDIN-1-YL}SULFONYL)-4-(5-FLUOROPYRIMIDIN-2-YL)-2-METHYLPENTAN-2-YL]-N-HYDROXYFORMAMIDE'>QHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAMTS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2h OCA], [https://pdbe.org/3q2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2h RCSB], [https://www.ebi.ac.uk/pdbsum/3q2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2h OCA], [https://pdbe.org/3q2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2h RCSB], [https://www.ebi.ac.uk/pdbsum/3q2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ATS1_HUMAN ATS1_HUMAN]] Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.<ref>PMID:10438512</ref>
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[https://www.uniprot.org/uniprot/ATS1_HUMAN ATS1_HUMAN] Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.<ref>PMID:10438512</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gerhardt, S]]
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[[Category: Gerhardt S]]
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[[Category: Hargreaves, D]]
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[[Category: Hargreaves D]]
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[[Category: Adamts1 zn-metalloprotease]]
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[[Category: Disintegrin]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metalloproteinase]]
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[[Category: Thrombospondin motif]]
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Current revision

Adamts1 in complex with N-hydroxyformamide inhibitors of ADAM-TS4

PDB ID 3q2h

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OCA

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