This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3qg2
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='3qg2' size='340' side='right'caption='[[3qg2]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3qg2' size='340' side='right'caption='[[3qg2]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3qg2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QG2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [https://pdbe.org/3qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qg2 OCA], [https://pdbe.org/3qg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qg2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qg2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 28: | Line 27: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Plafa]] | ||
| - | [[Category: Chitnumsub, P]] | ||
| - | [[Category: Kamchonwongpaisan, S]] | ||
| - | [[Category: Taweechai, S]] | ||
| - | [[Category: Vanichtanankul, J]] | ||
| - | [[Category: Yuthavong, Y]] | ||
| - | [[Category: Yuvaniyama, J]] | ||
| - | [[Category: Antifolate resistance]] | ||
| - | [[Category: Dihydrofolate reductase]] | ||
| - | [[Category: Oxidoreductase]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
| - | [[Category: | + | [[Category: Chitnumsub P]] |
| - | [[Category: | + | [[Category: Kamchonwongpaisan S]] |
| - | [[Category: | + | [[Category: Taweechai S]] |
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Yuthavong Y]] | ||
| + | [[Category: Yuvaniyama J]] | ||
Current revision
Plasmodium falciparum DHFR-TS qradruple mutant (N51I+C59R+S108N+I164L, V1/S) pyrimethamine complex
| |||||||||||
