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3rdp

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Current revision (17:16, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3rdp' size='340' side='right'caption='[[3rdp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3rdp' size='340' side='right'caption='[[3rdp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rdp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rdp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RDP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NMF:6-[(2R)-2-(FLUOROMETHYL)-3-HYDROXY-PROPYL]-1,5-DIMETHYL-PYRIMIDINE-2,4-DIONE'>NMF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3f0t|3f0t]], [[1e2p|1e2p]], [[1e2h|1e2h]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NMF:6-[(2R)-2-(FLUOROMETHYL)-3-HYDROXY-PROPYL]-1,5-DIMETHYL-PYRIMIDINE-2,4-DIONE'>NMF</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TK, UL23 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10299 HHV-1])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdp OCA], [https://pdbe.org/3rdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rdp RCSB], [https://www.ebi.ac.uk/pdbsum/3rdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdp OCA], [https://pdbe.org/3rdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rdp RCSB], [https://www.ebi.ac.uk/pdbsum/3rdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rdp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hhv-1]]
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[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thymidine kinase]]
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[[Category: Ametamey S]]
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[[Category: Ametamey, S]]
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[[Category: Martic M]]
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[[Category: Martic, M]]
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[[Category: Pernot L]]
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[[Category: Pernot, L]]
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[[Category: Perozzo R]]
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[[Category: Perozzo, R]]
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[[Category: Scapozza L]]
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[[Category: Scapozza, L]]
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[[Category: Westermaier Y]]
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[[Category: Westermaier, Y]]
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[[Category: Atp-binding]]
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[[Category: Dna synthesis]]
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[[Category: Dna-synthesis]]
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[[Category: Early protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Pet tracer]]
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[[Category: Transferase]]
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Current revision

Crystal structure of thymidine kinase from herpes simplex virus type 1 in complex with N-METHYL-FHBT

PDB ID 3rdp

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