3to8

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Current revision (17:33, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3to8' size='340' side='right'caption='[[3to8]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='3to8' size='340' side='right'caption='[[3to8]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3to8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TO8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3to8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TO8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HNRNPL, HNRPL, P/OKcl.14 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3to8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3to8 OCA], [https://pdbe.org/3to8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3to8 RCSB], [https://www.ebi.ac.uk/pdbsum/3to8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3to8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3to8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3to8 OCA], [https://pdbe.org/3to8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3to8 RCSB], [https://www.ebi.ac.uk/pdbsum/3to8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3to8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/HNRPL_HUMAN HNRPL_HUMAN]] Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.<ref>PMID:11809897</ref>
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[https://www.uniprot.org/uniprot/HNRPL_HUMAN HNRPL_HUMAN] Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.<ref>PMID:11809897</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: Liu, Y W]]
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[[Category: Liu YW]]
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[[Category: Niu, L W]]
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[[Category: Niu LW]]
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[[Category: Teng, M K]]
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[[Category: Teng MK]]
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[[Category: Zeng, F X]]
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[[Category: Zeng FX]]
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[[Category: Zhang, W J]]
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[[Category: Zhang WJ]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Rna binding protein]]
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[[Category: Rna recognition motif]]
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[[Category: Splicing]]
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Current revision

Crystal structure of the two C-terminal RRM domains of heterogeneous nuclear ribonucleoprotein L (hnRNP L)

PDB ID 3to8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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