3u0w

<table><tr><td colspan='2'>[[3u0w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0W FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0w OCA], [https://pdbe.org/3u0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0w RCSB], [https://www.ebi.ac.uk/pdbsum/3u0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0w ProSAT]</span></td></tr>

== Disease ==

[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

== Function ==

[https://www.uniprot.org/uniprot/HVM38_MOUSE HVM38_MOUSE] [https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]

[[Category: Homo sapiens]]

[[Category: Mus musculus]]

[[Category: Crespi GAN]]

[[Category: Miles LA]]

[[Category: Parker MW]]