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5m12

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Current revision (18:19, 1 November 2023) (edit) (undo)
 
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<StructureSection load='5m12' size='340' side='right'caption='[[5m12]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='5m12' size='340' side='right'caption='[[5m12]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m12]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M12 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M12 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7D0:(1~{R},2~{S},3~{S},4~{R},5~{S},6~{S})-5-[3,5-BIS(FLUORANYL)PHENOXY]-1-(HYDROXYMETHYL)BICYCLO[4.1.0]HEPTANE-2,3,4-TRIOL'>7D0</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">galA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7D0:(1~{R},2~{S},3~{S},4~{R},5~{S},6~{S})-5-[3,5-BIS(FLUORANYL)PHENOXY]-1-(HYDROXYMETHYL)BICYCLO[4.1.0]HEPTANE-2,3,4-TRIOL'>7D0</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-galactosidase Alpha-galactosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.22 3.2.1.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m12 OCA], [https://pdbe.org/5m12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m12 RCSB], [https://www.ebi.ac.uk/pdbsum/5m12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m12 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m12 OCA], [http://pdbe.org/5m12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m12 RCSB], [http://www.ebi.ac.uk/pdbsum/5m12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m12 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGAL_THEMA AGAL_THEMA] Hydrolyzes the short-chain alpha-galactosaccharides raffinose, melibiose and stachyose.<ref>PMID:25486100</ref> <ref>PMID:9741105</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alpha-galactosidase]]
 
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[[Category: Atcc 43589]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gloster, T]]
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[[Category: Thermotoga maritima]]
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[[Category: Pengelly, R]]
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[[Category: Gloster T]]
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[[Category: Glycoside hydrolase]]
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[[Category: Pengelly R]]
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[[Category: Hydrolase]]
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Current revision

Structure of GH36 alpha-galactosidase from Thermotoga maritima in complex with intact cyclopropyl-carbasugar.

PDB ID 5m12

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