1o0d
From Proteopedia
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[[Image:1o0d.jpg|left|200px]] | [[Image:1o0d.jpg|left|200px]] | ||
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'''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor''' | '''Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor''' | ||
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[[Category: Mack, H.]] | [[Category: Mack, H.]] | ||
[[Category: Seitz, W.]] | [[Category: Seitz, W.]] | ||
- | [[Category: | + | [[Category: Ternary complex]] |
- | [[Category: | + | [[Category: Thrombin/active-site inhibitor/exo-site inhibitor]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:27 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 00:12, 3 May 2008
Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
Contents |
Overview
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
Disease
Known disease associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this Structure
1O0D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189 Page seeded by OCA on Sat May 3 03:12:27 2008