This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5m8d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:30, 1 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5m8d' size='340' side='right'caption='[[5m8d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='5m8d' size='340' side='right'caption='[[5m8d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5m8d]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M8D FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5m8d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M8D FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UGI:5-(6-MORPHOLIN-4-YL-2-PYRROLIDIN-1-YL-PYRIMIDIN-4-YL)-4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE'>UGI</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4o2b|4o2b]], [[5m7e|5m7e]], [[5m7g|5m7g]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UGI:5-(6-MORPHOLIN-4-YL-2-PYRROLIDIN-1-YL-PYRIMIDIN-4-YL)-4-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE'>UGI</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8d OCA], [http://pdbe.org/5m8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8d RCSB], [http://www.ebi.ac.uk/pdbsum/5m8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8d ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8d OCA], [https://pdbe.org/5m8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m8d RCSB], [https://www.ebi.ac.uk/pdbsum/5m8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
+
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
==See Also==
==See Also==
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
-
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
 
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
*[[Tubulin tyrosine ligase|Tubulin tyrosine ligase]]
-
*[[User:Alisa Cario|User:Alisa Cario]]
 
== References ==
== References ==
<references/>
<references/>
Line 30: Line 28:
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
 +
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Bohnacker, T]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Prota, A E]]
+
[[Category: Bohnacker T]]
-
[[Category: Steinmetz, M O]]
+
[[Category: Prota AE]]
-
[[Category: Wymann, M P]]
+
[[Category: Steinmetz MO]]
-
[[Category: Cell cycle]]
+
[[Category: Wymann MP]]
-
[[Category: Cytoskeleton]]
+
-
[[Category: Microtubule]]
+
-
[[Category: Tubulin fold]]
+

Current revision

Tubulin MTD265-R1 complex

PDB ID 5m8d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m8d"
Personal tools