1o0v

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[[Image:1o0v.jpg|left|200px]]
[[Image:1o0v.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1o0v |SIZE=350|CAPTION= <scene name='initialview01'>1o0v</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1o0v", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= IgE(ND) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1o0v| PDB=1o0v | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0v OCA], [http://www.ebi.ac.uk/pdbsum/1o0v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o0v RCSB]</span>
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}}
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'''The crystal structure of IgE Fc reveals an asymmetrically bent conformation'''
'''The crystal structure of IgE Fc reveals an asymmetrically bent conformation'''
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[[Category: Wan, T.]]
[[Category: Wan, T.]]
[[Category: Young, R J.]]
[[Category: Young, R J.]]
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[[Category: ige fc]]
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[[Category: Ige fc]]
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[[Category: immunoglobulin e]]
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[[Category: Immunoglobulin e]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:13:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:38:17 2008''
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Revision as of 00:13, 3 May 2008

Image:1o0v.jpg

Template:STRUCTURE 1o0v

The crystal structure of IgE Fc reveals an asymmetrically bent conformation


Overview

The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that replaces the hinge region of IgG. The crystal structure of the IgE Fc (constant fragment) at a 2.6-A resolution has revealed these domains. They display a distinctive, disulfide-linked Ig domain interface and are folded back asymmetrically onto the C epsilon 3 and C epsilon 4 domains, which causes an acute bend in the IgE molecule. The structure implies that a substantial conformational change involving C epsilon 2 must accompany binding to the mast cell receptor Fc epsilon RI. This may be the basis of the exceptionally slow dissociation rate of the IgE-Fc epsilon RI complex and, thus, of the ability of IgE to cause persistent allergic sensitization of mast cells.

About this Structure

1O0V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of IgE Fc reveals an asymmetrically bent conformation., Wan T, Beavil RL, Fabiane SM, Beavil AJ, Sohi MK, Keown M, Young RJ, Henry AJ, Owens RJ, Gould HJ, Sutton BJ, Nat Immunol. 2002 Jul;3(7):681-6. Epub 2002 Jun 17. PMID:12068291 Page seeded by OCA on Sat May 3 03:13:16 2008

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