1oyt

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(New page: 200px<br /> <applet load="1oyt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oyt, resolution 1.67&Aring;" /> '''COMPLEX OF RECOMBIN...)
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Revision as of 16:31, 12 November 2007

Image:1oyt.gif

1oyt, resolution 1.67Å

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COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR

Disease

Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]

About this Structure

1OYT is a Protein complex structure of sequences from Homo sapiens with NA, CA and FSN as ligands. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.

Reference

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions., Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Muller K, Diederich F, Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2507-11. PMID:12800172

Page seeded by OCA on Mon Nov 12 18:38:17 2007

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