8bd2

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Current revision (11:57, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8bd2 is ON HOLD until Paper Publication
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==Calcium-bound Calmodulin variant G113R==
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<StructureSection load='8bd2' size='340' side='right'caption='[[8bd2]]' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BD2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bd2 OCA], [https://pdbe.org/8bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bd2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM3_HUMAN CALM3_HUMAN] Catecholaminergic polymorphic ventricular tachycardia;Romano-Ward syndrome. The disease may be caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM3_HUMAN CALM3_HUMAN] Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:35568036, PubMed:16760425, PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).<ref>PMID:16760425</ref> <ref>PMID:31454269</ref> <ref>PMID:35568036</ref> (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity.<ref>PMID:35338844</ref> <ref>PMID:35446120</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Brohus M]]
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[[Category: Holler CV]]
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[[Category: Iwai H]]
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[[Category: Niemelae MA]]
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[[Category: Overgaard MT]]
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[[Category: Petersson NM]]
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[[Category: Wimmer R]]

Current revision

Calcium-bound Calmodulin variant G113R

PDB ID 8bd2

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OCA

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