8bgi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==GABA-A receptor a5 homomer - a5V1 - Flumazenil== | |
| - | + | <StructureSection load='8bgi' size='340' side='right'caption='[[8bgi]], [[Resolution|resolution]] 2.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bgi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BGI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FYP:ethyl+8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate'>FYP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P9N:Pregnanolone'>P9N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bgi OCA], [https://pdbe.org/8bgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bgi RCSB], [https://www.ebi.ac.uk/pdbsum/8bgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bgi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GBRA5_HUMAN GBRA5_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aricescu AR]] | ||
| + | [[Category: Malinauskas TM]] | ||
| + | [[Category: Miller PS]] | ||
| + | [[Category: Omari KE]] | ||
Revision as of 11:57, 8 November 2023
GABA-A receptor a5 homomer - a5V1 - Flumazenil
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