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3w0t
From Proteopedia
(Difference between revisions)
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<StructureSection load='3w0t' size='340' side='right'caption='[[3w0t]], [[Resolution|resolution]] 1.35Å' scene=''> | <StructureSection load='3w0t' size='340' side='right'caption='[[3w0t]], [[Resolution|resolution]] 1.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3w0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3w0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0T FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HPU:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDROPYRIDIN-2-YL)PHENYL]METHANESULFONAMIDE'>HPU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.351Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HPU:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDROPYRIDIN-2-YL)PHENYL]METHANESULFONAMIDE'>HPU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0t OCA], [https://pdbe.org/3w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0t RCSB], [https://www.ebi.ac.uk/pdbsum/3w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0t ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0t OCA], [https://pdbe.org/3w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0t RCSB], [https://www.ebi.ac.uk/pdbsum/3w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fukami | + | [[Category: Fukami TA]] |
| - | [[Category: Irie | + | [[Category: Irie M]] |
| - | [[Category: Matsuura | + | [[Category: Matsuura T]] |
| - | + | ||
| - | + | ||
Current revision
Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor
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