3w7r

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Current revision (12:56, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3w7r' size='340' side='right'caption='[[3w7r]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='3w7r' size='340' side='right'caption='[[3w7r]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W7R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W7R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W7A:2,6-DIOXO-5-[2-(4-PHENYLPHENYL)ETHYL]-1,2,3,6-+TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7A</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3w71|3w71]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W7A:2,6-DIOXO-5-[2-(4-PHENYLPHENYL)ETHYL]-1,2,3,6-+TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>W7A</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7r OCA], [https://pdbe.org/3w7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w7r RCSB], [https://www.ebi.ac.uk/pdbsum/3w7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w7r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w7r OCA], [https://pdbe.org/3w7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w7r RCSB], [https://www.ebi.ac.uk/pdbsum/3w7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w7r ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aoki, T]]
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[[Category: Aoki T]]
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[[Category: Balogun, E O]]
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[[Category: Balogun EO]]
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[[Category: Harada, S]]
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[[Category: Harada S]]
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[[Category: Hashimoto, S]]
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[[Category: Hashimoto S]]
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[[Category: Honma, T]]
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[[Category: Honma T]]
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[[Category: Iida, M]]
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[[Category: Iida M]]
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[[Category: Inaoka, D K]]
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[[Category: Inaoka DK]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kita, K]]
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[[Category: Kita K]]
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[[Category: Kuranaga, T]]
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[[Category: Kuranaga T]]
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[[Category: Lee, N]]
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[[Category: Lee N]]
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[[Category: Matsuoka, S]]
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[[Category: Matsuoka S]]
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[[Category: Nara, T]]
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[[Category: Nara T]]
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[[Category: Sakamoto, K]]
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[[Category: Sakamoto K]]
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[[Category: Shiba, T]]
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[[Category: Shiba T]]
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[[Category: Suzuki, S]]
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[[Category: Suzuki S]]
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[[Category: Tabuchi, T]]
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[[Category: Tabuchi T]]
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[[Category: Tanaka, A]]
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[[Category: Tanaka A]]
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[[Category: Dihydroorotate/orotate and ubiquinone/ubiquinol]]
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[[Category: Mitochondrial inner membrane]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Rossmann fold]]
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Current revision

Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097

PDB ID 3w7r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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