3wan

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Current revision (13:01, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wan' size='340' side='right'caption='[[3wan]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
<StructureSection load='3wan' size='340' side='right'caption='[[3wan]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wan]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wan]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vtu|3vtu]], [[3vtv|3vtv]], [[3vtw|3vtw]], [[3wal|3wal]], [[3wam|3wam]], [[3wao|3wao]], [[3wap|3wap]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP1LC3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wan OCA], [https://pdbe.org/3wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wan RCSB], [https://www.ebi.ac.uk/pdbsum/3wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wan ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wan OCA], [https://pdbe.org/3wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wan RCSB], [https://www.ebi.ac.uk/pdbsum/3wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wan ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref>
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[https://www.uniprot.org/uniprot/MLP3A_HUMAN MLP3A_HUMAN] Involved in formation of autophagosomal vacuoles (autophagosomes).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dobson, R C.J]]
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[[Category: Dobson RCJ]]
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[[Category: Kato, R]]
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[[Category: Kato R]]
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[[Category: Kawasaki, M]]
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[[Category: Kawasaki M]]
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[[Category: Morita, E]]
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[[Category: Morita E]]
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[[Category: Suzuki, H]]
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[[Category: Suzuki H]]
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[[Category: Tabata, K]]
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[[Category: Tabata K]]
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[[Category: Wakatsuki, S]]
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[[Category: Wakatsuki S]]
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[[Category: Yoshimori, T]]
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[[Category: Yoshimori T]]
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[[Category: Autophagy]]
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[[Category: Protein binding]]
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[[Category: Ubiquitin-like fold]]
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Current revision

Crystal structure of Atg13 LIR-fused human LC3A_2-121

PDB ID 3wan

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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