3wek

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Current revision (13:07, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wek' size='340' side='right'caption='[[3wek]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3wek' size='340' side='right'caption='[[3wek]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PS7:{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL+TRIHYDROGEN+DIPHOSPHATE'>PS7</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vj8|3vj8]], [[3vj9|3vj9]], [[3vja|3vja]], [[3vjb|3vjb]], [[3vjc|3vjc]], [[3vjd|3vjd]], [[3wef|3wef]], [[3weg|3weg]], [[3weh|3weh]], [[3wei|3wei]], [[3wej|3wej]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PS7:{(1R,2R,3R)-2-[(3E)-4,8-DIMETHYLNONA-3,7-DIEN-1-YL]-2-METHYL-3-[(1E,5E)-2,6,10-TRIMETHYLUNDECA-1,5,9-TRIEN-1-YL]CYCLOPROPYL}METHYL+TRIHYDROGEN+DIPHOSPHATE'>PS7</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDFT1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wek OCA], [https://pdbe.org/3wek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wek RCSB], [https://www.ebi.ac.uk/pdbsum/3wek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wek ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wek OCA], [https://pdbe.org/3wek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wek RCSB], [https://www.ebi.ac.uk/pdbsum/3wek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wek ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Squalene synthase]]
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[[Category: Jeng WY]]
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[[Category: Jeng, W Y]]
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[[Category: Liu CI]]
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[[Category: Liu, C I]]
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[[Category: Wang AHJ]]
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[[Category: Wang, A H.J]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Farnesyl-diphosphate farnesyltransferase]]
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[[Category: Head-to-head synthase]]
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[[Category: Oxidoreductase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the human squalene synthase F288L mutant in complex with presqualene pyrophosphate

PDB ID 3wek

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OCA

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