3wh3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:10, 8 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3wh3' size='340' side='right'caption='[[3wh3]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
<StructureSection load='3wh3' size='340' side='right'caption='[[3wh3]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3wh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WH3 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3wh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WH3 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wh2|3wh2]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLEC4E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wh3 OCA], [https://pdbe.org/3wh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wh3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wh3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wh3 OCA], [https://pdbe.org/3wh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wh3 RCSB], [https://www.ebi.ac.uk/pdbsum/3wh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wh3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/CLC4E_HUMAN CLC4E_HUMAN]] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
+
[https://www.uniprot.org/uniprot/CLC4E_HUMAN CLC4E_HUMAN] C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Furukawa, A]]
+
[[Category: Furukawa A]]
-
[[Category: Kamishikiryo, J]]
+
[[Category: Kamishikiryo J]]
-
[[Category: Kanda, R]]
+
[[Category: Kanda R]]
-
[[Category: Maenaka, K]]
+
[[Category: Maenaka K]]
-
[[Category: Miyake, Y]]
+
[[Category: Miyake Y]]
-
[[Category: Mori, D]]
+
[[Category: Mori D]]
-
[[Category: Okabe, Y]]
+
[[Category: Okabe Y]]
-
[[Category: Ose, T]]
+
[[Category: Ose T]]
-
[[Category: Toji, A]]
+
[[Category: Toji A]]
-
[[Category: Toyonaga, K]]
+
[[Category: Toyonaga K]]
-
[[Category: Yamasaki, S]]
+
[[Category: Yamasaki S]]
-
[[Category: C-type lectin]]
+
-
[[Category: Carbohydrate recognition]]
+
-
[[Category: Glycolipid binding]]
+
-
[[Category: Immune system]]
+
-
[[Category: Plasmamembrane]]
+

Current revision

human Mincle, ligand free form

PDB ID 3wh3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3wh3"
Personal tools