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3wx2

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Current revision (13:32, 8 November 2023) (edit) (undo)
 
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<StructureSection load='3wx2' size='340' side='right'caption='[[3wx2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3wx2' size='340' side='right'caption='[[3wx2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WX2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WX2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wx1|3wx1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crbn ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [https://pdbe.org/3wx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wx2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wx2 OCA], [https://pdbe.org/3wx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wx2 RCSB], [https://www.ebi.ac.uk/pdbsum/3wx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wx2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
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[https://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Hakoshima, T]]
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[[Category: Hakoshima T]]
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[[Category: Handa, H]]
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[[Category: Handa H]]
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[[Category: Hirano, Y]]
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[[Category: Hirano Y]]
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[[Category: Ito, T]]
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[[Category: Ito T]]
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[[Category: Mori, T]]
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[[Category: Mori T]]
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[[Category: Yamaguchi, Y]]
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[[Category: Yamaguchi Y]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: Metal binding protein]]
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[[Category: Zinc finger]]
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Current revision

Mouse Cereblon thalidomide binding domain, native

PDB ID 3wx2

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