This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1p4f
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1p4f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p4f, resolution 1.90Å" /> '''DEATH ASSOCIATED PR...)
Next diff →
Revision as of 16:33, 12 November 2007
|
DEATH ASSOCIATED PROTEIN KINASE CATALYTIC DOMAIN WITH BOUND INHIBITOR FRAGMENT
Overview
Death associated protein kinase (DAPK) is a calcium and calmodulin, regulated enzyme that functions early in eukaryotic programmed cell death, or apoptosis. To validate DAPK as a potential drug discovery target for, acute brain injury, the first small molecule DAPK inhibitor was, synthesized and tested in vivo. A single injection of the, aminopyridazine-based inhibitor administered 6 h after injury attenuated, brain tissue or neuronal biomarker loss measured, respectively, 1 week and, 3 days later. Because aminopyridazine is a privileged structure in, neuropharmacology, we determined the high-resolution crystal structure of, a binary complex between the kinase domain and a molecular fragment of the, DAPK inhibitor. The co-crystal structure describes a structural basis for, interaction and provides a firm foundation for structure-assisted design, of lead compounds with appropriate molecular properties for future drug, development.
About this Structure
1P4F is a Single protein structure of sequence from Homo sapiens with DRG as ligand. Full crystallographic information is available from OCA.
Reference
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury., Velentza AV, Wainwright MS, Zasadzki M, Mirzoeva S, Schumacher AM, Haiech J, Focia PJ, Egli M, Watterson DM, Bioorg Med Chem Lett. 2003 Oct 20;13(20):3465-70. PMID:14505650
Page seeded by OCA on Mon Nov 12 18:39:54 2007
