1o5w
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1o5w.jpg|left|200px]] | [[Image:1o5w.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1o5w", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_1o5w| PDB=1o5w | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A''' | '''The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A''' | ||
| Line 23: | Line 20: | ||
==Reference== | ==Reference== | ||
Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors., Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T, J Mol Biol. 2004 Apr 16;338(1):103-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15050826 15050826] | Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors., Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T, J Mol Biol. 2004 Apr 16;338(1):103-14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15050826 15050826] | ||
| - | [[Category: Amine oxidase (flavin-containing)]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 32: | Line 28: | ||
[[Category: Yamashita, E.]] | [[Category: Yamashita, E.]] | ||
[[Category: Yoshimura, M.]] | [[Category: Yoshimura, M.]] | ||
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:25:37 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:25, 3 May 2008
The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A
Overview
Monoamine oxidase (MAO), a mitochondrial outer membrane enzyme, catalyzes the degradation of neurotransmitters in the central nervous system and is the target for anti-depression drug design. Two subtypes of MAO, MAOA and MAOB, are similar in primary sequences but have unique substrate and inhibitor specificities. The structures of human MAOB complexed with various inhibitors were reported early. To understand the mechanisms of specific substrate and inhibitor recognitions of MAOA and MAOB, we have determined the crystal structure of rat MAOA complexed with the specific inhibitor, clorgyline, at 3.2A resolution. The comparison of the structures between MAOA and MAOB clearly explains the specificity of clorgyline for MAOA inhibition. The fitting of serotonin into the binding pockets of MAOs demonstrates that MAOB Tyr326 would block access of the 5-hydroxy group of serotonin into the enzyme. These results will lead to further understanding of the MAOA function and to new anti-depression drug design. This study also presents that MAOA has a transmembrane helix at the C-terminal region. This is the first crystal structure of membrane protein with an isolated transmembrane helix.
About this Structure
1O5W is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of rat monoamine oxidase A and its specific recognitions for substrates and inhibitors., Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T, J Mol Biol. 2004 Apr 16;338(1):103-14. PMID:15050826 Page seeded by OCA on Sat May 3 03:25:37 2008
