5vbl

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Current revision (16:50, 8 November 2023) (edit) (undo)
 
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<StructureSection load='5vbl' size='340' side='right'caption='[[5vbl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5vbl' size='340' side='right'caption='[[5vbl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VBL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=200:4-CHLORO-L-PHENYLALANINE'>200</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HRG:L-HOMOARGININE'>HRG</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OIC:OCTAHYDROINDOLE-2-CARBOXYLIC+ACID'>OIC</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=200:4-CHLORO-L-PHENYLALANINE'>200</scene>, <scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=HRG:L-HOMOARGININE'>HRG</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OIC:OCTAHYDROINDOLE-2-CARBOXYLIC+ACID'>OIC</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APLNR, AGTRL1, APJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1501 "Bacillus pasteurianus" (Winogradsky 1895) Lehmann and Neumann 1907])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbl OCA], [https://pdbe.org/5vbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbl RCSB], [https://www.ebi.ac.uk/pdbsum/5vbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vbl OCA], [https://pdbe.org/5vbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vbl RCSB], [https://www.ebi.ac.uk/pdbsum/5vbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vbl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN]] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
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[https://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.[https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clostridium pasteurianum]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Han, G W]]
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[[Category: Han GW]]
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[[Category: Hanson, M A]]
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[[Category: Hanson MA]]
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[[Category: Hu, L A]]
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[[Category: Hu LA]]
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[[Category: Li, C]]
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[[Category: Li C]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: Ma, X]]
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[[Category: Ma X]]
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[[Category: Ma, Y]]
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[[Category: Ma Y]]
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[[Category: Shen, Y]]
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[[Category: Shen Y]]
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[[Category: Sickmier, E A]]
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[[Category: Sickmier EA]]
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[[Category: Song, Y]]
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[[Category: Song Y]]
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[[Category: Stevems, R C]]
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[[Category: Stevems RC]]
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[[Category: Swaminath, G]]
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[[Category: Swaminath G]]
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[[Category: Xu, F]]
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[[Category: Xu F]]
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[[Category: Yue, Y]]
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[[Category: Yue Y]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Zhang, Q]]
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[[Category: Zhang Q]]
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[[Category: Zhao, S]]
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[[Category: Zhao S]]
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[[Category: Zhong, W]]
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[[Category: Zhong W]]
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[[Category: Zhou, Q]]
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[[Category: Zhou Q]]
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[[Category: Agonist peptide]]
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[[Category: Amg3054]]
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[[Category: Binding specificity]]
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[[Category: Cardiovascular drug target]]
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[[Category: Designed agonist peptide mimic]]
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[[Category: Gpcr]]
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[[Category: Human apelin receptor complex]]
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[[Category: Isopeptide]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Peptide-gcpr recognition]]
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[[Category: Rubredoxin]]
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[[Category: Specific recognition]]
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[[Category: Synchrotron radiation]]
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Current revision

Structure of apelin receptor in complex with agonist peptide

PDB ID 5vbl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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