This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5mmv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:40, 8 November 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='5mmv' size='340' side='right'caption='[[5mmv]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5mmv' size='340' side='right'caption='[[5mmv]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5mmv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MMV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5mmv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MMV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WE0:(3~{S})-3-[[(3~{S})-2-[(2~{S})-3-methyl-2-(naphthalen-2-ylcarbonylamino)butanoyl]-4-oxidanyl-2-azabicyclo[2.2.2]octan-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>WE0</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-1 Caspase-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.36 3.4.22.36] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WE0:(3~{S})-3-[[(3~{S})-2-[(2~{S})-3-methyl-2-(naphthalen-2-ylcarbonylamino)butanoyl]-4-oxidanyl-2-azabicyclo[2.2.2]octan-3-yl]carbonylamino]-4-oxidanyl-butanoic+acid'>WE0</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmv OCA], [http://pdbe.org/5mmv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mmv RCSB], [http://www.ebi.ac.uk/pdbsum/5mmv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmv ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mmv OCA], [https://pdbe.org/5mmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mmv RCSB], [https://www.ebi.ac.uk/pdbsum/5mmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mmv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN]] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
+
[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
==See Also==
==See Also==
Line 17: Line 17:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Caspase-1]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Brethon, A]]
+
[[Category: Brethon A]]
-
[[Category: Chantalat, L]]
+
[[Category: Chantalat L]]
-
[[Category: Christin, O]]
+
[[Category: Christin O]]
-
[[Category: Clary, L]]
+
[[Category: Clary L]]
-
[[Category: Fournier, J F]]
+
[[Category: Fournier JF]]
-
[[Category: Gastreich, M]]
+
[[Category: Gastreich M]]
-
[[Category: Harris, C]]
+
[[Category: Harris C]]
-
[[Category: Isabet, T]]
+
[[Category: Isabet T]]
-
[[Category: Pascau, J]]
+
[[Category: Pascau J]]
-
[[Category: Roche, D]]
+
[[Category: Roche D]]
-
[[Category: Rodeschin, V]]
+
[[Category: Rodeschin V]]
-
[[Category: Thoreau, E]]
+
[[Category: Thoreau E]]
-
[[Category: Hydrolase]]
+
-
[[Category: Inflammatory disease]]
+
-
[[Category: Nanomolar inhibitor]]
+
-
[[Category: Sp3 hybridization]]
+

Current revision

Crystal structure of human Caspase-1 with 2-((2-naphthoyl)-L-valyl)-4-hydroxy-N-((3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide (Compound 1)

PDB ID 5mmv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5mmv"
Personal tools