5ms3

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<StructureSection load='5ms3' size='340' side='right'caption='[[5ms3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5ms3' size='340' side='right'caption='[[5ms3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ms3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MS3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MS3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ms3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MS3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLK8, NRPN, PRSS19, TADG14, UNQ283/PRO322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kallikrein_8 Kallikrein 8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.118 3.4.21.118] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ms3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ms3 OCA], [https://pdbe.org/5ms3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ms3 RCSB], [https://www.ebi.ac.uk/pdbsum/5ms3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ms3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ms3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ms3 OCA], [http://pdbe.org/5ms3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ms3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ms3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ms3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLK8_HUMAN KLK8_HUMAN]] Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.<ref>PMID:16337200</ref>
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[https://www.uniprot.org/uniprot/KLK8_HUMAN KLK8_HUMAN] Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.<ref>PMID:16337200</ref>
==See Also==
==See Also==
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*[[Kallikrein|Kallikrein]]
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Kallikrein 8]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bode, W]]
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[[Category: Bode W]]
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[[Category: Brandstetter, H]]
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[[Category: Brandstetter H]]
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[[Category: Debela, M]]
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[[Category: Debela M]]
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[[Category: Goettig, P]]
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[[Category: Goettig P]]
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[[Category: Magdolen, V]]
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[[Category: Magdolen V]]
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[[Category: Skala, W]]
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[[Category: Skala W]]
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[[Category: Ca2+ complex]]
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[[Category: Free active site]]
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[[Category: Hydrolase]]
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[[Category: Synaptic remodeling]]
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[[Category: Trypsin-like serine protease]]
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Current revision

Kallikrein-related peptidase 8 calcium complex

PDB ID 5ms3

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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