|
|
| Line 3: |
Line 3: |
| | <StructureSection load='5n2u' size='340' side='right'caption='[[5n2u]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='5n2u' size='340' side='right'caption='[[5n2u]], [[Resolution|resolution]] 2.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5n2u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_d_virus_(d/bovine/france/2986/2012) Influenza d virus (d/bovine/france/2986/2012)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N2U FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5n2u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_D_virus_(D/bovine/France/2986/2012) Influenza D virus (D/bovine/France/2986/2012)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2U FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1542973 Influenza D virus (D/bovine/France/2986/2012)])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2u OCA], [http://pdbe.org/5n2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2u RCSB], [http://www.ebi.ac.uk/pdbsum/5n2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2u ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2u OCA], [https://pdbe.org/5n2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2u RCSB], [https://www.ebi.ac.uk/pdbsum/5n2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2u ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A0A0E3VZU8_9ORTO A0A0E3VZU8_9ORTO] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 18: |
Line 20: |
| | | | |
| | ==See Also== | | ==See Also== |
| - | *[[Nucleoprotein|Nucleoprotein]] | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| Line 24: |
Line 26: |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Crepin, T]] | + | [[Category: Crepin T]] |
| - | [[Category: Labaronne, A]] | + | [[Category: Labaronne A]] |
| - | [[Category: Ruigrok, R W.H]] | + | [[Category: Ruigrok RWH]] |
| - | [[Category: Influenza virus]]
| + | |
| - | [[Category: Nucleoprotein]]
| + | |
| - | [[Category: Viral protein]]
| + | |
| Structural highlights
Function
A0A0E3VZU8_9ORTO
Publication Abstract from PubMed
This paper focuses on the nucleoprotein (NP) of the newly identified member of the Orthomyxoviridae family, Influenza D virus. To date several X-ray structures of NP of Influenza A (A/NP) and B (B/NP) viruses and of infectious salmon anemia (ISA/NP) virus have been solved. Here we purified, characterized and solved the X-ray structure of the tetrameric D/NP at 2.4 A resolution. The crystal structure of its core is similar to NP of other Influenza viruses. However, unlike A/NP and B/NP which possess a flexible amino-terminal tail containing nuclear localization signals (NLS) for their nuclear import, D/NP possesses a carboxy-terminal tail (D/NPTAIL). We show that D/NPTAIL harbors a bipartite NLS and designed C-terminal truncated mutants to demonstrate the role of D/NPTAIL for nuclear transport.
The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport.,Donchet A, Oliva J, Labaronne A, Tengo L, Miloudi M, C A Gerard F, Mas C, Schoehn G, W H Ruigrok R, Ducatez M, Crepin T Sci Rep. 2019 Jan 24;9(1):600. doi: 10.1038/s41598-018-37306-y. PMID:30679709[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Donchet A, Oliva J, Labaronne A, Tengo L, Miloudi M, C A Gerard F, Mas C, Schoehn G, W H Ruigrok R, Ducatez M, Crepin T. The structure of the nucleoprotein of Influenza D shows that all Orthomyxoviridae nucleoproteins have a similar NPCORE, with or without a NPTAIL for nuclear transport. Sci Rep. 2019 Jan 24;9(1):600. doi: 10.1038/s41598-018-37306-y. PMID:30679709 doi:http://dx.doi.org/10.1038/s41598-018-37306-y
|
