1p8x
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(New page: 200px<br /> <applet load="1p8x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p8x, resolution 2.0Å" /> '''The Calcium-Activate...)
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Revision as of 16:34, 12 November 2007
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The Calcium-Activated C-terminal half of gelsolin
Contents |
Overview
Gelsolin requires activation to carry out its severing and capping, activities on F-actin. Here, we present the structure of the isolated, C-terminal half of gelsolin (G4-G6) at 2.0 A resolution in the presence of, Ca(2+) ions. This structure completes a triptych of the states of, activation of G4-G6 that illuminates its role in the function of gelsolin., Activated G4-G6 displays an open conformation, with the actin-binding site, on G4 fully exposed and all three type-2 Ca(2+) sites occupied. Neither, actin nor the type-l Ca(2+), which normally is sandwiched between actin, and G4, is required to achieve this conformation.
Disease
Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]
About this Structure
1P8X is a Single protein structure of sequence from Homo sapiens with CA as ligand. Full crystallographic information is available from OCA.
Reference
Activation in isolation: exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin., Narayan K, Chumnarnsilpa S, Choe H, Irobi E, Urosev D, Lindberg U, Schutt CE, Burtnick LD, Robinson RC, FEBS Lett. 2003 Sep 25;552(2-3):82-5. PMID:14527664
Page seeded by OCA on Mon Nov 12 18:41:03 2007
