7yaa

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'''Unreleased structure'''
 
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The entry 7yaa is ON HOLD until 2024-11-10
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==Crystal structure analysis of cp3 bound BCLxl==
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<StructureSection load='7yaa' size='340' side='right'caption='[[7yaa]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7yaa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YAA FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JJ9:N-(2-acetamidoethyl)-4-(4-methanoyl-1,3-thiazol-2-yl)benzamide'>JJ9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yaa OCA], [https://pdbe.org/7yaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yaa RCSB], [https://www.ebi.ac.uk/pdbsum/7yaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yaa ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Li FW]]
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[[Category: Liu C]]
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[[Category: Wu CL]]
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[[Category: Wu DL]]

Revision as of 07:29, 15 November 2023

Crystal structure analysis of cp3 bound BCLxl

PDB ID 7yaa

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