8uq2

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'''Unreleased structure'''
 
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The entry 8uq2 is ON HOLD
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==Structure of human RyR2-S2808D in the subprimed state==
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<StructureSection load='8uq2' size='340' side='right'caption='[[8uq2]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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Authors: Miotto, M.C., Marks, A.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8uq2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ2 FirstGlance]. <br>
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Description: Structure of human RyR2-S2808D in the subprimed state
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Miotto, M.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq2 OCA], [https://pdbe.org/8uq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uq2 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq2 ProSAT]</span></td></tr>
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[[Category: Marks, A.R]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Marks AR]]
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[[Category: Miotto MC]]

Revision as of 07:44, 15 November 2023

Structure of human RyR2-S2808D in the subprimed state

PDB ID 8uq2

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