8uq4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8uq4" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8uq4 is ON HOLD until sometime in the future
+
==Structure of human RyR2-S2808D in the subprimed state in the presence of H2O2/NOC-12/GSH==
-
 
+
<StructureSection load='8uq4' size='340' side='right'caption='[[8uq4]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
-
Authors: Miotto, M.C., Marks, A.R.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8uq4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ4 FirstGlance]. <br>
-
Description: Structure of human RyR2-S2808D in the subprimed state in the presence of NOC-12/GSH
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.64&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Miotto, M.C]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq4 OCA], [https://pdbe.org/8uq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq4 ProSAT]</span></td></tr>
-
[[Category: Marks, A.R]]
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Marks AR]]
 +
[[Category: Miotto MC]]

Revision as of 07:44, 15 November 2023

Structure of human RyR2-S2808D in the subprimed state in the presence of H2O2/NOC-12/GSH

PDB ID 8uq4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8uq4"
Personal tools