1o94

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[[Image:1o94.jpg|left|200px]]
[[Image:1o94.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1o94 |SIZE=350|CAPTION= <scene name='initialview01'>1o94</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1o94", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Sf4+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trimethylamine_dehydrogenase Trimethylamine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.8.2 1.5.8.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1o94| PDB=1o94 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o94 OCA], [http://www.ebi.ac.uk/pdbsum/1o94 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o94 RCSB]</span>
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}}
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'''TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN'''
'''TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN'''
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[[Category: Sutcliffe, M J.]]
[[Category: Sutcliffe, M J.]]
[[Category: Talfournier, F.]]
[[Category: Talfournier, F.]]
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[[Category: dehydrogenase]]
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[[Category: Dehydrogenase]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:32:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:41:44 2008''
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Revision as of 00:32, 3 May 2008

Image:1o94.jpg

Template:STRUCTURE 1o94

TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN


Overview

Here we report the crystal structures of a ternary electron transfer complex showing extensive motion at the protein interface. This physiological complex comprises the iron-sulfur flavoprotein trimethylamine dehydrogenase and electron transferring flavoprotein (ETF) from Methylophilus methylotrophus. In addition, we report the crystal structure of free ETF. In the complex, electron density for the FAD domain of ETF is absent, indicating high mobility. Positions for the FAD domain are revealed by molecular dynamics simulation, consistent with crystal structures and kinetic data. A dual interaction of ETF with trimethylamine dehydrogenase provides for dynamical motion at the protein interface: one site acts as an anchor, thereby allowing the other site to sample a large range of interactions, some compatible with rapid electron transfer. This study establishes the role of conformational sampling in multi-domain redox systems, providing insight into electron transfer between ETFs and structurally distinct redox partners.

About this Structure

1O94 is a Protein complex structure of sequences from Methylophilus methylotrophus. Full crystallographic information is available from OCA.

Reference

Extensive conformational sampling in a ternary electron transfer complex., Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS, Nat Struct Biol. 2003 Mar;10(3):219-25. PMID:12567183 Page seeded by OCA on Sat May 3 03:32:30 2008

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