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1w9u

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Current revision (08:08, 15 November 2023) (edit) (undo)
 
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<StructureSection load='1w9u' size='340' side='right'caption='[[1w9u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='1w9u' size='340' side='right'caption='[[1w9u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspfm Aspfm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus] and [https://en.wikipedia.org/wiki/Clonostachys Clonostachys]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=0AR:N-[N-[(4S)-4-AZANYL-5-HYDROXY-5-OXO-PENTYL]CARBAMIMIDOYL]ETHANAMIDE'>0AR</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=UN1:2-AMINOHEXANEDIOIC+ACID'>UN1</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0AR:N-[N-[(4S)-4-AZANYL-5-HYDROXY-5-OXO-PENTYL]CARBAMIMIDOYL]ETHANAMIDE'>0AR</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UN1:2-AMINOHEXANEDIOIC+ACID'>UN1</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w9p|1w9p]], [[1w9v|1w9v]]</div></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9u OCA], [https://pdbe.org/1w9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9u RCSB], [https://www.ebi.ac.uk/pdbsum/1w9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9u OCA], [https://pdbe.org/1w9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9u RCSB], [https://www.ebi.ac.uk/pdbsum/1w9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9u ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHIB1_ASPFM CHIB1_ASPFM] Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspfm]]
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[[Category: Aspergillus fumigatus]]
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[[Category: Chitinase]]
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[[Category: Clonostachys]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aalten, D M.F van]]
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[[Category: Adams DJ]]
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[[Category: Adams, D J]]
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[[Category: Aerts JMFG]]
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[[Category: Aerts, J M.F G]]
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[[Category: Boot RG]]
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[[Category: Boot, R G]]
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[[Category: Hodkinson M]]
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[[Category: Hodkinson, M]]
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[[Category: Houston DR]]
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[[Category: Houston, D R]]
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[[Category: Omura S]]
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[[Category: Omura, S]]
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[[Category: Rao FV]]
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[[Category: Rao, F V]]
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[[Category: Shiomi K]]
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[[Category: Shiomi, K]]
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[[Category: Van Aalten DMF]]
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[[Category: Argadin]]
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[[Category: Chitinase inhibitor]]
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[[Category: Cyclopentapeptide inhibitor]]
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[[Category: Glycosidase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

Specificity and affnity of natural product cyclopentapeptide inhibitor Argadin against Aspergillus fumigatus chitinase

PDB ID 1w9u

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OCA

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